Journal
TETRAHEDRON LETTERS
Volume 57, Issue 25, Pages 2749-2753Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2016.05.018
Keywords
N-alkylation; Palladium; Tin; Amine; Alcohol
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Funding
- DST
- UGC
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The N-alkylation of amines, and amides with benzyl alcohols is catalyzed by bimetallic catalyst [Pd(COD) (SnCl3)Cl] in o-xylene. The reaction does not require additional base, additive or ligand, and is insensitive toward air and moisture and involves minimal work-up. These features make the reaction attractive, simple, and practical. (C) 2016 Elsevier Ltd. All rights reserved.
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