4.4 Article

The application of NCTS (N-cyano-N-phenyl-p-toluenesulfonamide) in palladium-catalyzed cyanation of arenediazonium tetrafluoroborates and aryl halides

Journal

TETRAHEDRON LETTERS
Volume 57, Issue 11, Pages 1205-1209

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2016.01.033

Keywords

Cyanation; Palladium-catalyzed; Arenediazonium tetrafluoroborates; Aryl halides; NCTS

Funding

  1. Natural Science Foundation of Jilin Province, China [20130101004JC, 3D513P491412]
  2. National Nature Science Foundation of China (NSFC) [51573069]

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Using NCTS (N-cyano-N-phenyl-p-toluenesulfonamide) as an electrophilic cyanation reagent, palladium-catalyzed cyanation of arenediazonium tetrafluoroborates and aryl halides was achieved under mild conditions. The method allowed the effective synthesis of various aryl nitriles in suitable yields via a coupling reaction. (C) 2016 Elsevier Ltd. All rights reserved.

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