4.4 Article

A one-pot synthesis of trichloromethylated pyrimidines from trichloroacetimidamides and acetylenic esters

Journal

TETRAHEDRON LETTERS
Volume 57, Issue 16, Pages 1733-1735

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2015.12.066

Keywords

Pyrimidine; Trichloroacetonitrile; Tetramethylguanidine; Acetylenic ester

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A one-pot synthesis of functionalized trichloromethylated pyrimidines from the reaction of trichloroacetimidamides, generated by the addition of guanidine derivatives to trichloroacetonitrile, and acetylenic esters, in good yields is described. (C) 2016 Published by Elsevier Ltd.

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