Journal
TETRAHEDRON
Volume 72, Issue 47, Pages 7496-7504Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2016.09.068
Keywords
2-Aryl/alkyl-5-bromo-7-methoxy benzofurans; Egonol; Homoegonol; Heck reaction; Synthesis
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We herein report the general, versatile, and convenient method for the synthesis of 2-arly/alkyl-5-bromo-7-methoxy benzofurans from easily available o-Vanillin in five steps. These benzofurans was successfully converted into biological active natural products Egonol, Homoegonol, and analogous on applying Heck reaction using ethyl/methyl acrylate in the presence of palladium catalyst. (C) 2016 Elsevier Ltd. All rights reserved.
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