Journal
TETRAHEDRON
Volume 72, Issue 41, Pages 6536-6542Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2016.08.067
Keywords
Multi-component reaction; Pyrrolo[1,2-a]quinoxaline; Propargyl alcohol; Palladium-catalyzed reaction
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Funding
- Research Council of the Shahrood University of Technology
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1,4-Disubstituted pyrrolo[1,2-a]quinoxalines were prepared through the one-pot multi-component reactions of 3-substituted-2-chloroquinoxalines, propargyl alcohol, and secondary amines, catalyzed by Pd/Cu, in the presence of K2CO3 and sodium dodecyl sulfate (SDS) in water. This process provided a facile, eco-friendly, and highly efficient method for the synthesis of new pyrrolo[1,2-a]quinoxalines in water with good yields. (C) 2016 Elsevier Ltd. All rights reserved.
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