Journal
TETRAHEDRON
Volume 72, Issue 22, Pages 3092-3097Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2016.04.032
Keywords
Deep-sea-derived fungus; Simplicillium; obclavatum; Linear peptide; Antifouling; Cytotoxicity
Categories
Funding
- Strategic Leading Special Science and Technology Program of Chinese Academy of Sciences [XDA100304002]
- National Natural Science Foundation of China [41376160]
- National Marine Public Welfare Research Project of China [201305017]
- Regional Innovation Demonstration Project of Guangdong Province Marine Economic Development [GD2012-D01-002]
- National High Technology Research and Development Program of China (863 Program) [2012AA092104]
- Marine Fishery Science and Technology Promotion Project of Guangdong Province [A201301B05]
- Science and Technology Project of Guangdong Province [2010B030600009]
Ask authors/readers for more resources
Eight new linear peptides, simplicilliumtides A-H (1-8) were isolated from a culture broth of the deep-sea-derived fungal strain Simplicillium obclavatum EIODSF 020. Their structures were elucidated by spectroscopic analysis, and their absolute configurations were determined by Marfey's method. Compounds 1-2 are linear tetrapeptides possessing a 2-aminobenzoic acid residue. Compounds 3-8 are acetylated linear tri- or di-peptides. Their antifouling, antibacterial, cytotoxic, and acetylcholinesterase inhibiting activities were evaluated. Compound 4 showed strong antifouling activity against Bugula neritina larvae settlement. And 1, 5, 7 and 8 showed weak cytotoxicity towards human leukemia HL-60 or K562 cell line. (C) 2016 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
