Journal
TETRAHEDRON
Volume 72, Issue 32, Pages 4910-4917Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2016.06.061
Keywords
Asterothamnus centrali-asiaticus; Sesquiterpenes; Asterothamnones; Benzofuran derivatives
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Funding
- National Nature Science Foundation of China [21375136, 21575150]
- scientific research project of Central Asia Drug Discovery and Development Centre of Chinese Academy of Sciences [CAM201404]
- CAS Pioneer Hundred Talents Program
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Phytochemical investigation on Asterothamnus centrali-asiaticus afforded four new sesquiterpenes, asterothamnones A-D (1-4), and three new benzofuran derivatives (5-7) together with ten known compounds (8-17). Their structures were elucidated using 1D and 2D NMR and X-ray diffraction analyses. Compounds 1-4 were verified to be unusual eudesmane sesquiterpenes possessing 4,6-dien-3-one or 1,4,6-triene-3-one conjugated system. The absolute configurations of compounds 1-8 were established by means of calculated electronic circular dichroism (ECD). Furthermore, all isolates were evaluated for their cytotoxic and anti-oxidant activities. Results showed that 10, 12 and, 14 exhibited cytotoxic activity against HepG2 cancer cells and 14 displayed cytotoxicity against MGC-803 cancer cells. Compounds 10 and 17 showed anti-oxidant effect. (C) 2016 Elsevier Ltd. All rights reserved.
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