Journal
TETRAHEDRON
Volume 72, Issue 13, Pages 1645-1652Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2016.02.029
Keywords
Vitamin A; beta-Ionone; Arens-van Dorp reaction; Wittig reaction; Julia Olefination
Categories
Funding
- Royal Society
- EPSRC
- Engineering and Physical Sciences Research Council [1344412] Funding Source: researchfish
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The advances made in chemistry during the last 70 years are excellently illustrated by the development of the industrial synthesis of vitamin A, a diterpene crucial in preventing premature death and visual problems. Arens and van Dorp published the first route in 1946, and critical contributions have been made by a number of scientists since, benefitting from fruitful collaborations between industry and academia. However, these improvements have been mostly incremental, and the work has been performed by a limited number of companies; as yet, there is still no 'ideal' synthesis of vitamin A. (C) 2016 Elsevier Ltd. All rights reserved.
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