Journal
TALANTA
Volume 154, Issue -, Pages 80-84Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.talanta.2016.03.057
Keywords
Iron (III); Ferric; Wine; Carbon nanotubes; FET sensors; Transferrin
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Funding
- University of Cordoba (Spain)
- University of Aveiro (Portugal)
- Asociacion Universitaria Iberoamericana de Postgrado (AUIP)
- Regional Ministry of Economy and Knowledge of the Andalusia Government (Spain)
- FCT/MEC (PIDDAC) [IF/00407/2013/CP1162/CT0023]
- Portuguese Science Foundation (FCT) [UID/AMB/50017/2013]
- FCT through POCH funds [SFRH/BPD/95961/2013]
- European Social Fund
- Portuguese National Funds from MEC
- FCT through the Associated Lab - Instituto de Nanotecnologias (IN)
- Fundação para a Ciência e a Tecnologia [IF/00407/2013/CP1162/CT0023] Funding Source: FCT
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This paper reports the tuning of a fast, disposable, and label-free biosensor for quantification of iron (III) in food liquid samples such as wine. The biosensor is based on a field effect transistor(FET) where a net work of single-walled carbonnanotubes (SWCNTs) acts as the conductor channel, constituting carbonnanotubes field effect transistors (CNTFETs). An antibody such as transferrin with two specific high affinity iron (III) binding sites, directly adsorbed to SWCNTs, was used as immunoreaction. Several individual CNTFETs were tested showing a linear range between 0.05 and 2 ng mL(-1) and a limit of quantification below 0.05 ng mL(-1), much lower than previously reported analytical techniques. The mean coefficient of variation was 0.13% showing a low variability of the analytical response. On the other hand, it was not observed interference effect of zinc (II) ion at least until 1:4 iron-zinc ratio. Finally, recovery percentages of spiked wine samples were around 100%, showing the high accuracy of method. The main advantages of the devices developed are their speed, convenience (it is an economical method), and the avoidance excessive handling samples since they do not require further pre-treatment of samples. (c) 2016 Elsevier B.V. All rights reserved.
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