Journal
TALANTA
Volume 161, Issue -, Pages 721-729Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.talanta.2016.09.034
Keywords
Capillary LC; Surface glycosylation; Graft copolymerization; HILIC; Monolith
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Funding
- National Natural Science Foundation of China [B050102]
- Natural Science Foundation of Hunan Province [14JJ7034]
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A facile, flexible process was developed for the preparation of surface-glycosylated porous monolithic columns via aqueous two-phase graft copolymerization of polyethylene glycol diacrylate (PEGDA) and water-soluble dextran (dextran sulfate). The formation of poly(PEGDA) porous skeletons and surface glycosylation were achieved via a one-step process without pre-modification of the dextran. The synthesis conditions were thoroughly optimized. The optimal monolithic column exhibited a large dry state surface area (greater than 400 m(2)/g), and it was evaluated as a hydrophilic liquid chromatography (HILIC) stationary phase. A typical HILIC mechanism was observed at high organic solvent content (>= 65% acetonitrile). In addition, the resulting monolithic column demonstrated the potential use in analysis of complex biological sample and enviroment water.
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