Journal
TALANTA
Volume 161, Issue -, Pages 592-598Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.talanta.2016.09.008
Keywords
Fluorescent; Near-infrared; Hypochlorous acid; Cell imaging
Categories
Funding
- National Natural Science Foundation of China [21302187, 21475134, 21507135, 91439101]
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Hypochlorous acid (HOCl) is a kind of reactive oxygen species which plays an important role in biological process. HOCl detection is of great importance in disease prevention and treatment. Herein, a cyanine-based near-infrared (NIR) fluorescent probe for HOC! has been designed and synthesized. This probe can react with HOC! in a dose-response manner along with the fluorescence of the probe quenched, the reaction through an electrophilic addition to the double bond and subsequent oxidation reaction. Experiments indicate that the probe can be acted as a selective and sensitive indicator for HOCl and the limit of detection for HOC! is estimated to be 22 nM. What's more, this probe shows a low toxicity to cells and can be applied to visualize HOCl molecules in living cells. Therefore, the proposed method may make a significant contribution to HOCl detection. (C) 2016 Elsevier B.V. All rights reserved.
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