Journal
TALANTA
Volume 161, Issue -, Pages 888-893Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.talanta.2016.08.051
Keywords
DNA cross-linking; Mitochondria-targeted; Nitrogen mustard; Near infrared fluorescence emission; Gel electrophoresis; Cell apoptosis analysis
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Funding
- National Science Foundation of China [21572147]
- China Postdoctoral Science Foundation [2014M560718]
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In this report, the design of two novel nitrogen mustard-based DNA cross-linking agents with fluorophores incorporated into the structure (TN-A and TN-B) is disclosed. The results indicate that TN-A and TN-B can serve directly as both reporting and imaging agents for flow cytometry and gel electrophoresis without the necessity of another fluorescent tagging agents. TN-A and TN-B both selectively locate in the mitochondria and exhibit good antitumor activity. Notably, TN-A is the first DNA crosslinking agent with near infrared fluorescence emission properties.
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