Journal
TALANTA
Volume 151, Issue -, Pages 114-118Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.talanta.2016.01.017
Keywords
Creatinine; Phosphotungstic acid; Poly(ethyleneimine); Layer-by-Layer self-assembly; Electrochemical sensors
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Funding
- Graduate Student Research Innovation Project of Xinjiang [XJGRI2014018]
- Natural Sciences Foundation of China [51541308, 21565023]
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In this work, the direct determination of creatinine was achieved using a poly(ethyleneimine)/phosphotungstic acid multilayer modified electrode with the assistance of Copper(II) ions by cyclic voltammetry. The quantity of creatinine were determined by measuring the redox peak current of Cu(II)creatinine complex/Cu(I)-creatinine complex. Factors affecting the response current of creatinine at the modified electrode were optimized. A linear relationship between the response current and the concentration of creatinine ranging from 0.125 to 62.5 mu M was obtained with a detection limit of 0.06 mu M. The proposed method was applied to determine creatinine in human urine, and satisfied results were gotten which was validated in accordance with high performance liquid chromatography. The proposed electrode provided a promising alternative in routine sensing for creatinine without enzymatic assistance. (C) 2016 Elsevier B.V. All rights reserved.
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