Journal
TALANTA
Volume 147, Issue -, Pages 445-452Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.talanta.2015.10.019
Keywords
MaT-cyclen; H2S detection; Confocal; Zebra fish
Categories
Funding
- Ministry of Science and Technology
- Ministry of Health and Welfare of the Republic of China [NSC 103-2627-M-009-001, NSC 101-2923-M-009-002, MOHW104-TDU-B-212-124-003]
- National Chiao Tung University
- Ministry of Education
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According to the displacement method, herein we reported a water soluble copper complex [Cu(MaT-cyclen)(2)] as a fluorescent probe for the detection of H2S. For this, 1((1-(10-methylanthracen-9-yl)methyl)-1H-1,2,3-triazol-4-yl)methyl)-1,4,7,10-tetraazacyclododecane (MaT-cyclen) was synthesized first To improve its solubility in aqueous media, sodium acetate group was introduced into 8-hydroxy-2-quinoline successfully. MaT-cyclen was chelated with Cu(II) to form [Cu(MaT-cyclen)2] complex, which displayed high sensitivity and selectivity for H2S over the other possible competitive substances on the basis of forming CuS. Meanwhile, [Cu(MaT-cyclen)(2)] displayed rapid response (< 1 min), well reversibility, lowest detection limit (205 nM), and high sensitivity for recognizing H2S in aqueous solution. Furthermore, its potential utility for biological applications was confirmed by fluorescence imaging of H2S in live cells as well as in zebra fish. (C) 2015 Elsevier B.V. All rights reserved.
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