Journal
SYSTEMS BIOLOGY IN REPRODUCTIVE MEDICINE
Volume 62, Issue 4, Pages 249-257Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/19396368.2016.1182234
Keywords
Bisphenol A; Cordyceps militaris; reproductive damage; testis
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Funding
- High-end Foreign Experts Recruitment Program [GDW20146100228]
- Key Construction Program of International Cooperation Base in S&T, Shaanxi Province [2015SD0018]
- Construction Project of Shaanxi Collaborative Innovation Center (Shaanxi University of Technology), China
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This study aimed to investigate the protective effects of Cordyceps militaris (C. militaris) against reproductive damage induced by bisphenol A (BPA). Rats were administrated 200 mg/kg BPA for 4 weeks and treated with C. militaris (200, 400, and 800 mg/kg body weight/day). By the end of the fourth week, the level of oxidative damage, sperm parameters, hormone levels, and histopathological changes were examined. In the group that only received BPA, there was a significant decrease in body weight compared with the normal control (NC) group. C. militaris significantly alleviated the BPA-induced reproductive damage by increasing testicular superoxide dismutase (SOD), glutathione peroxidase (GSH-PX), and glutathione (GSH); as well as by reducing serum malondialdehyde (MDA). C. militaris not only obviously enhanced the levels of serum LH and T, but it also improved the sperm count and motility compared to the BPA-treated group. These results suggest that C. militaris could be used as a potential natural substance for preventing BPA induced reproductive damage.
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