Cadmium(II) and indium(III) complexes derived from 2-benzoylpyridine N(4)-cyclohexylthiosemicarbazone: Synthesis, crystal structures, spectroscopic characterization and cytotoxicity

Two metal complexes [Cd(L)(2)]center dot 0.275H(2)O(1) and [In(L)(2)]NO3 (2) (HL=2-benzoylpyridine N(4)-cyclohexylthiosemicarbazone) have been synthesized and structurally characterized by elemental analysis, a number of spectroscopic methods (IR, UV-vis, NMR), mass spectrometry, and X-ray crystallography. The Schiffs base ligand forms hexacoordinated complexes having octahedral geometry for Cd(II) and In(III) complexes, respectively. The synthesized compounds were tested for antiproliferative activity and showed the ability to kill HepG2 cells (human hepato cellular carcinoma) significantly, especially 2 with IC50= 2.02 +/- 0.14 mu M. Of particular note is the fact that complex 1 has c alpha 12-fold lower toxicity in the normal hepatocyte QSG7701 cells than in the hepatocellular carcinoma HepG2 cells. In addition, complex 2 also exhibited excellent luminescent property. Upon the addition of 1 equiv of In3+ ion, 200-fold fluorescence enhancement of HL at lambda(em)=504 nm has been observed. Moreover, the fluorescent color change (from transparent to light-green) could be observed by naked eyes under the light of 365 nm. These findings can expand the applications of thiosemicarbazone derivatives in the fields of colorimetric and fluorescent probes. (C) 2016 Elsevier B.V. All rights reserved.