Journal
SYNTHETIC COMMUNICATIONS
Volume 46, Issue 8, Pages 645-672Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/00397911.2016.1165254
Keywords
Fused system; ionic liquid; nanoparticles; pyrimidine; synthesis
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Funding
- Department of Science and Technology-FTYS, New Delhi, India [SB/FT/CS-126/2012]
- VIT University
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This review is an attempt to compile the literature of various synthetic procedures of pyrimidine analogs. Pyrimidine and its fused pyrimidine derivatives are a class of heterocyclic scaffolds that demonstrates a broad range of biological and pharmacological activities such as anticancer, anxiolytic, antioxidant, antiviral, antifungal, anticonvulsant, antidepressant, and antibacterial activities. According to World Health Organization reports, cancer remains a major cause of death in worldwide and there is a need to develop an effective drug against cancer. The literature indicated that pyrimidine motifs acts as anticancer agents, which motivates the researchers to design a series of pyrimidine heterocycles. [GRAPHICS] .
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