Recent Progress on Copper-Mediated Directing-Group-Assisted C(sp2)-H Activation

Considerable progress has been made in the area of copper-mediated C(sp(2))-H functionalization reactions with the assistance of chelating directing groups. Due to the advantages of copper catalysts such as low cost, low toxicity, and unique reactivity compared to precious metals, they have attracted more and more attention in organic synthesis. This review summarizes recent advances in this field according to the classification of directing groups. 1 Introduction 2 The Pyridine Directing Group 2.1 C-N Bond Formation 2.2 C-O Bond Formation 2.3 C-S Bond Formation 2.4 C-C Bond Formation 2.5 C-CN Bond Formation 2.6 C-Halogen Bond Formation 3 Bidentate Directing Groups 3.1 8-Aminoquinoline 3.2 (2-Pyridyl) Sulfonyl and Picolinic Acid 3.3 Amide-Oxazoline Auxiliary 3.4 2-(Pyridin-2-yl) isopropylamine (PIP Amine) 3.5 2-Aminopyridine 1-Oxide 4 Conclusions and Outlook