4.5 Article

Synthesis of Alkoxymethyl Groups Containing Isoxazoles and Chromones

Journal

SYNTHESIS-STUTTGART
Volume 49, Issue 5, Pages 1122-1130

Publisher

GEORG THIEME VERLAG KG
DOI: 10.1055/s-0036-1588327

Keywords

isoxazoles; chromones; electrophile-mediated cyclization; oxocarbenium ion

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An oxocarbenium ion mediated cyclization of (Z)-1,3-diaryl-prop-2-yn-1-one O-methyloximes and 3-arylprop-2-yn-1-(2-methoxyphenyl)-1-ones resulted in regioselective formation of functionalized isoxazoles and chromones, respectively. Alkoxy(aryl) methyl group containing compounds were obtained in good and high yields.

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