Copper-Catalyzed Silylcupration of Activated Alkynes

A highly efficient catalytic silylcupration of activated alkynes is reported. Upon reaction with silylboronates and methanol in THF at room temperature in the presence of copper(I) fluoride tris(triphenylphosphine), a range of ynamides and propiolates were found to undergo a smooth silylcupration. This reaction, which tolerates various functional groups, affords a straightforward and efficient entry to the corresponding beta-silylenamides and -acrylates, which were formed with high levels of regio-and stereoselectivities.