4.4 Article

A One-Pot Synthesis of Highly Functionalized Indolizines by 1,3-Dipolar Cycloaddition of Azomethine Ylides and Phosphorylated Hydroxyketenimines

Journal

SYNLETT
Volume 27, Issue 18, Pages 2601-2605

Publisher

GEORG THIEME VERLAG KG
DOI: 10.1055/s-0035-1562523

Keywords

Nef reaction; Perkow reaction; cascade reaction; indolizines; dipolar cycloaddition; azomethine ylides

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Alkyl 2-(alkylamino)-3-(quinolin-2-yl)indolizine-1-carboxylates were prepared by1,3-dipolar cycloaddition of azomethine ylides with phosphorylated hydroxyketenimines, generated in situ by a Nef isocyanide-Perkow cascade.

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