Journal
SYNLETT
Volume 28, Issue 1, Pages 64-67Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0036-1589414
Keywords
thiophosphate; thiolysis; phosphorylation; prebiotic chemistry; cyanosulfidic
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Funding
- Medical Research Council
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Described are our preliminary studies on the reactivity of thiophosphate in a setting which correlates with the cyanosulfidic systems chemistry we have previously reported. Thiophosphate adds to various nitrile groups giving the corresponding thioamides in a highly efficient manner and the mechanistic implications are briefly discussed. Thiophosphate can also act as a phosphorylating agent, which was demonstrated with adenosine. The prebiotic availability of thiophosphate must be questioned, but if a plausible synthesis can be found, the advantages it would bring to the field of prebiotic chemistry appear to be highly beneficial.
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