Journal
CLINICAL & TRANSLATIONAL ONCOLOGY
Volume 18, Issue 8, Pages 769-775Publisher
SPRINGER INT PUBL AG
DOI: 10.1007/s12094-015-1465-x
Keywords
Cabozantinib; Calcitonin; Carcinoembryonic antigen; Medullary thyroid carcinoma; Thyroid cancer; Review; Vandetanib
Categories
Ask authors/readers for more resources
Of all thyroid cancers, < 5 % are medullary (MTC). It is a well-characterized neuroendocrine tumor arising from calcitonin-secreting C cells, and RET gene plays a central role on its pathogeny. The electronic search was conducted using MEDLINE (PubMed), EMBASE and Cochrane Central Register of Controlled Trials. Quality assessments of selected current articles, guidelines and reviews of MTC were performed. This consensus updates and summarizes biology, treatment and prognostic considerations of MTC. Multidisciplinary teams and specialized centers are recommended for the management of MTC patients. In the metastatic setting, those patients with large volume of disease are candidates to start systemic treatment mainly if they are symptomatic and the tumor has progressed in the last 12-14 months. Wait and see strategy should be offered to patients with: disseminated disease with only high levels of calcitonin and no macroscopic structural disease, low burden and absence of progression.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available