Journal
SYNLETT
Volume 27, Issue 17, Pages 2505-2509Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0035-1562480
Keywords
addition; homogeneous catalysis; oxygenations; peroxides; radical reaction; sulfoxides
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Funding
- Chinese Scholarship Council
- DFG [KL 2221/4-1]
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An oxidative variant of the thiol-ene reaction has been developed, achieving the direct addition of thiols to olefins to form sulfoxides. The reaction uses tert-butyl hydroperoxide as oxidant and methanesulfonic acid as catalyst. The latter is believed to catalyze the oxidation of the intermediate sulfide to the sulfoxide. No special precautions are necessary to exclude oxygen, yet the products are formed without oxidation at the -position. Styrenes, acrylic acid derivatives, alkynes, and thiophenols gave the highest yields, while aliphatic olefins and thiols were less effective.
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