Journal
SWISS MEDICAL WEEKLY
Volume 146, Issue -, Pages -Publisher
E M H SWISS MEDICAL PUBLISHERS LTD
DOI: 10.4414/smw.2016.14347
Keywords
ESCRT; endosomal sorting; MVB biogenesis; membrane remodelling; signal transduction; nuclear envelope; neurodegeneration; viral infection; cancer
Categories
Funding
- AIRC Investigator Grant [15954]
- Telethon Grant [GPP13225]
- Cariplo Foundation
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Originally discovered as regulators of cargo sorting during endosomal trafficking, ESCRT (endosomal sorting complexes required for transport) proteins are emerging as flexible machines that shape the behaviour of membranes throughout the cell. Deregulation of ESCRT activity is observed in neuro-degenerative diseases, virus infection and cancer. However, the mechanisms of pathogenesis involving ESCRTs have not yet fully come into focus. Here, we review the current knowledge of ESCRT function in health and disease and provide educated guesses for future research and focused therapeutic intervention.
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