Journal
SUPRAMOLECULAR CHEMISTRY
Volume 29, Issue 6, Pages 441-445Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10610278.2016.1266359
Keywords
Metal-organic framework; nanoparticles; bioimaging; drug delivery; endocytosis
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Funding
- Institute for Basic Science (IBS) [IBS-R007-D1]
- National Research Foundation of Korea (NRF)-Korea government (MSIP) [2016R1C1B2010838]
- National Research Foundation of Korea [2016R1C1B2010838] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Tb-based metal-organic framework nanoparticles (Tb-MOF NPs) with good colloidal stability and stable fluorescence properties in an aqueous solution were prepared by a simple mechanical grinding of Tb-MOF with a biocompatible polymer surfactant (F127). The characteristic fluorescence property of Tb-MOF NPs allowed us to use this nanomaterial as a cell imaging probe. Efficient cellular uptake of Tb-MOF NPs apparently via an energy-dependent endocytosis was observed by confocal laser scanning microscopy. By taking advantage of the porous nature of the Tb-MOF NPs an anticancer drug (doxorubicin) was successfully loaded and delivered to kill cancer cells to demonstrate their usage as a drug delivery vehicle. This simple grinding method afforded a nanosized, multifunctional biomaterial that was used for cell imaging and drug delivery, and it can be extended to other MOFs to widen their applications. [GRAPHICS]
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