Journal
STEROIDS
Volume 107, Issue -, Pages 98-111Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.steroids.2015.12.023
Keywords
Pregnenolone; Thiophene; 1,2,4-Triazole; Pyran; Anti-inflammatory; Antiulcer activity
Funding
- Deanship of Scientific Research at King Saud University [RG-1435-083]
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The reaction of pregnenolone with cyanoacetylhydrazine and ammonium acetate at 120 degrees C gave the Knoevenagel condensation product 3. The latter reacted with different reagents to give thiophene, thieno[2,3-d]pyrimidine, 1,2,4-triazole and pyran derivatives. The anti-inflammatory and anti-ulcer evaluations of the newly synthesized products were evaluated and the results showed that compounds 4, 8c, 10, 11, 13c, 15a, 15c, 17a, 17b, 17e, 18a and 18f possessed higher activity compared to the rest of the compounds. In addition to this, the toxicity of these active compounds was studied against shrimp larvae where compounds 15a, 15c and 18a showed non-toxicity against the tested organisms. (C) 2016 Elsevier Inc. All rights reserved.
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