Journal
STEM CELLS
Volume 34, Issue 8, Pages 1997-2007Publisher
WILEY
DOI: 10.1002/stem.2406
Keywords
Cancer stem cell; Epithelial-mesenchymal transition; Tumor heterogeneity; Therapeutic resistance
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Funding
- MEXT KAKENHI [25461995, 16K10473]
- Grants-in-Aid for Scientific Research [16K10473, 25461995] Funding Source: KAKEN
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Cancer stem cells (CSCs) constitute a small subpopulation of cancer cells with stem-like properties that are able to self-renew, generate differentiated daughter cells, and give rise to heterogeneous tumor tissue. Tumor heterogeneity is a hallmark of cancer and underlies resistance to anticancer therapies and disease progression. The epithelial-mesenchymal transition (EMT) is a reversible phenomenon that is mediated by EMT-inducing transcription factors (EMT-TFs) and plays an important role in normal organ development, wound healing, and the invasiveness of cancer cells. Recent evidence showing that overexpression of several EMT-TFs is associated with stemness in cancer cells has suggested the existence of a link between EMT and CSCs. In this review, we focus on the roles of CSCs and EMT signaling in driving tumor heterogeneity. A better understanding of the dynamics of both CSCs and EMT-TFs in the generation of tumor heterogeneity may provide a basis for the development of new treatment options for cancer patients.
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