Journal
STEM CELLS
Volume 34, Issue 6, Pages 1702-1707Publisher
WILEY
DOI: 10.1002/stem.2359
Keywords
Glioblastoma; Brain tumor initiating cells; Microfluidics; Molecular heterogeneity
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Funding
- National Institutes of Health [K99CA151673-01A1]
- Department of Defense [W81XWH-10-1-0500]
- Hagey Family Endowed Fund in Stem Cell Research and Regenerative Medicine
- Oak Foundation
- Ludwig Institute
- Thomas and Stacey Siebel Foundation
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Brain tumor-initiating cells (BTICs) are self-renewing multipotent cells critical for tumor maintenance and growth. Using single-cell microfluidic profiling, we identified multiple subpopulations of BTICs coexisting in human glioblastoma, characterized by distinct surface marker expression and single-cell molecular profiles relating to divergent bulk tissue molecular subtypes. These data suggest BTIC subpopulation heterogeneity as an underlying source of intra-tumoral bulk tissue molecular heterogeneity, and will support future studies into BTIC subpopulation-specific therapies.
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