Journal
STEM CELLS
Volume 35, Issue 1, Pages 9-16Publisher
WILEY-BLACKWELL
DOI: 10.1002/stem.2446
Keywords
Post-translational modification; Ubiquitination; Deubiquitination; Deubiquitinating enzymes; Pluripotency; Differentiation; Spermatogenesis; Oogenesis
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Funding
- National Research Foundation of Korea [201500000002885, 2015H1D3A1036065, 2015R1D1A1A01060907]
- National Research Foundation of Korea [2015H1D3A1036065, 2015R1D1A1A01060907, 2015R1C1A1A01054482] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Post-translational modification by ubiquitin molecules is a key regulatory process for stem cell fate determination. Ubiquitination and deubiquitination are the major cellular processes used to balance the protein turnover of several transcription factors that regulate stem cell differentiation. Deubiquitinating enzymes (DUBs), which facilitate the processing of ubiquitin, significantly influence stem cell fate choices. Specifically, DUBs play a critical regulatory role during development by directing the production of new specialized cells. This review focuses on the regulatory role of DUBs in various cellular processes, including stem cell pluripotency and differentiation, adult stem cell signaling, cellular reprogramming, spermatogenesis, and oogenesis. Specifically, the identification of interactions of DUBs with core transcription factors has provided new insight into the role of DUBs in regulating stem cell fate determination. Thus, DUBs have emerged as key pharmacologic targets in the search to develop highly specific agents to treat various illnesses.
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