Journal
STEM CELL REVIEWS AND REPORTS
Volume 12, Issue 6, Pages 621-633Publisher
SPRINGER
DOI: 10.1007/s12015-016-9690-4
Keywords
Mesenchymal stem cell; Autophagy; Stemness; Differentiation; Hypoxia; Acidity; Senescence
Funding
- Italian Ministry of the Health
- Regione Emilia Romagna
Ask authors/readers for more resources
Regulated self-consumption, also known as autophagy, is an evolutionary conserved process that degrades cellular components by directing them to the lysosomal compartment of eukaryotic cells. As a major intracellular degradation and recycling pathway, autophagy is crucial for maintaining and remodeling cellular homeostasis during normal cellular and tissue development. Recent studies have demonstrated that autophagy is necessary for the maintenance of cellular stemness and for a number of differentiation processes, including the lineage determination of mesenchymal stem cells. These are multipotent progenitor cells with self-renewal capacities that can give rise to a subset of tissues and thus hold a consistent potential in regenerative medicine. Here, we review the current literature on the complex liaison between autophagy induced by various extra- or intracellular stimuli and the molecular targets that affect mesenchymal stem cells proliferation and differentiation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available