Journal
STEM CELL RESEARCH
Volume 16, Issue 1, Pages 116-119Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.scr.2015.12.014
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Funding
- Torres Quevedo Subprogram, Ministry of Economy and Competitiveness [PTQ-11-04777]
- Institute of Health Carlos III [PI13/00862]
- RETIC [RD12/0019/0031]
- Fundacion Bancaria Caja Navarra [70270]
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In this work we describe for the first time the generation and characterization of human induced pluripotent stem cells (hiPSCs) from peripheral blood mononuclear cells (PBMCs) and dermal fibroblasts of a Primary Hyperoxaluria Type I (PH1)-diagnosed patient with p.I244T mutation, which is highly prevalent in Canary Islands due to founder effect. Cell reprogramming was performed using non-integrative Sendai viruses containing the Yamanaka factors and the generated PH1-hiPSC lines (PH1-PBMCs-hiPSC4F1 and PH1-Fib-hiPSC4F1) showed normal karyotypes, silencing of the exogenous reprogramming factors, induction of the typical pluripotency-associated markers and in vivo differentiation ability to the three germ layers. (C) 2015 The Authors. Published by Elsevier B.V.
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