Journal
SOUTH AFRICAN JOURNAL OF BOTANY
Volume 102, Issue -, Pages 18-25Publisher
ELSEVIER
DOI: 10.1016/j.sajb.2015.06.018
Keywords
Allium cepa; Amaranthus spinosus; Antigenotoxicity; Genotoxicity; H2O2
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Funding
- Kerala State Council for Science, Technology & Environment through KSCSTE fellowship
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The aim of the present study was to evaluate the possible genotoxic effects of A. spinosus leaf extracts on Allium cepa root meristematic cells and its antigenotoxic effects against H2O2-induced genetic damage in A. cepa. The excessive reduction in mitotic index (MI) (A4, 3 h, 23.37 +/- 1.41) and extremely significant (P < 0.001) levels of clastogenicity (A4, 3 h, 98.14 +/- 0.70) was observed after genotoxicity assay. The clastogenic abnormalities observed include bizarre nucleus, chromosome bridges, cytomixis, etc. In antigenotoxicity studies, initial toxicity was induced by two concentrations (7% and 3%) of H2O2. Higher percentage of nuclear lesions in treatment with H2O2 (99.27 +/- 0.19) and its significant reduction after modulatory treatment (5 mg/L; 32.25 +/- 7.69) was observed in the results, and indicates the chemopreventive activity of the plant extract at a critical concentration (5 mg/L). Here, the extent of antimutagenicity at this specific concentration (5 mg/L) was strong as the percentage of inhibition was greater than 40% (67.51 +/- 8.68). The results demonstrated that the aqueous plant extract of A. spinosus have the ability to inhibit the oxidative damage induced by the direct-acting mutagen (H2O2) at a precise concentration. (C) 2015 SAAB. Published by Elsevier B.V. All rights reserved.
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