Journal
SMALL
Volume 13, Issue 8, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201602496
Keywords
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Funding
- Natural Science Foundation of China [21671046, 21161003, 21364002, 21502028, 51562001]
- Guangxi Natural Science Foundation of China [2013GXNSFGA019001, 2012GXNSFDA053007, 2014GXNSFBA118038]
- Program for New Century Excellent Talents in University of the Ministry of Education [NCET-13-0743]
- Program for New Century National Hundred, Thousand and Ten Thousand Talent Project of Guangxi
- State Key Laboratory Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources [CMEMR2015-A01, CMEMR2013-A08, CMEMR2013-A013]
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Malignant melanoma is a highly aggressive tumor resistant to chemotherapy. Therefore, the development of new highly effective therapeutic agents for the treatment of malignant melanoma is highly desirable. In this study, a new class of polymeric photothermal agents based on poly(N-phenylglycine) (PNPG) suitable for use in near-infrared (NIR) phototherapy of malignant melanoma is designed and developed. PNPG is obtained via polymerization of N-phenylglycine (NPG). Carboxylate functionality of NPG allows building multifunctional systems using covalent bonding. This approach avoids complicated issues typically associated with preparation of polymeric photothermal agents. Moreover, PNPG skeleton exhibits pH-responsive NIR absorption and an ability to generate reactive oxygen species, which makes its derivatives attractive photothermal therapy (PTT)/photodynamic therapy (PDT) dual-modal agents with pH-responsive features. PNPG is modified using hyaluronic acid (HA) and polyethylene glycol diamine (PEG-diamine) acting as the coupling agent. The resultant HA-modified PNPG (PNPG-PEG-HA) shows negligible cytotoxicity and effectively targets CD44-overexpressing cancer cells. Furthermore, the results of in vitro and in vivo experiments reveal that PNPG-PEG-HA selectively kills B16 cells and suppresses malignant melanoma tumor growth upon exposure to NIR light (808 nm), indicating that PNPG-PEG-HA can serve as a very promising nanoplatform for targeted dual-modality PTT/PDT of melanoma.
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