Journal
SMALL
Volume 12, Issue 41, Pages 5750-5758Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201601696
Keywords
-
Categories
Funding
- National Natural Science Foundation of China [51525203, 51302180, 51572180]
- National 973 Program of China [2012CB932601]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Post-doctoral science foundation of China [2013M531400, 2014T70542]
- University of Wisconsin-Madison
- National Institutes of Health [NIBIB/NCI 1R01CA169365, P30CA014520, 5T32GM08349]
- National Science Foundation [DGE-1256259]
- American Cancer Society [125246-RSG-13-099-01-CCE]
- Collaborative Innovation Center of Suzhou Nano Science and Technology (Nano-CIC)
Ask authors/readers for more resources
While position emission tomography (PET) is an important molecular imaging technique for both preclinical research and clinical disease diagnosis/prognosis, chelator-free radiolabeling has emerged as a promising alternative approach to label biomolecules or nanoprobes in a facile way. Herein, starting from bottom-up synthesized WS2 nanoflakes, this study fabricates a unique type of WS2/WOx nanodots, which can function as inherent hard oxygen donor for stable radiolabeling with Zirconium-89 isotope (Zr-89). Upon simply mixing, Zr-89 can be anchored on the surface of polyethylene glycol (PEG) modified WS2/WOx (WS2/WOx-PEG) nanodots via a chelator-free method with surprisingly high labeling yield and great stability. A higher degree of oxidation in the WS2/WOx-PEG sample (WS2/WOx (0.4)) produces more electron pairs, which would be beneficial for chelator-free labeling of Zr-89 with higher yields, suggesting the importance of surface chemistry and particle composition to the efficiency of chelator-free radiolabeling. Such Zr-89-WS2/WOx (0.4)-PEG nanodots are found to be an excellent PET contrast agent for in vivo imaging of tumors upon intravenous administration, or mapping of draining lymph nodes after local injection.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available