Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 232, Issue -, Pages 484-491Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2016.03.153
Keywords
Reduced graphene Oxide-BaYF5:Yb; Er nanocomposites; Surface assembly; Carcinoembryonic antigen; Electrochemiluminescence immunosensor
Funding
- Jiangsu Collaborative Innovation Center of Biomedical Functional Materials
- Priority Academic Program Development of Jiangsu Higher Education Institution
- National Natural Science Foundation of China [21571104]
- Natural Science Foundation of Jiangsu Province of China [BK 20131396]
- Natural Sciences of University in Jiangsu Province of China [14KJA150006]
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We reported a novel ECL immunosensor for detection of carcinoembryonic antigen (CEA) based on the reduced graphene Oxide-BaYF5:Yb, Er (rGO-BaYF5:Yb, Er) nanocomposites. The rGO-BaYF5:Yb, Er nanocomposites, used as electrode luminescence materials, were prepared by in situ hydrothermal method, and characterized by TEM, XRD, UV-vis spectra, and upconversion fluorescence spectra. Further, poly (diallyldimethylammonium chloride) (PDDA), Au nanoparticles (AuNPs), and Anti-CEA were successively assembled on the surface of rGO-BaYF5:Yb, Er nanocomposites modified-electrode for fabricating ECL immunosensor. The results of the ECL measurements of CEA indicated that this novel ECL immunosensor exhibited high sensitive response to CEA in a linear range of 0.001-80 ng mL(-1) with a low detection limit of 0.87 pgmL(-1), good selectivity and satisfactory stability. (C) 2016 Elsevier B.V. All rights reserved.
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