Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 236, Issue -, Pages 459-465Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2016.06.004
Keywords
Fluorescent probe; High sensitivity; Specific; Fast response; Hypochlorite; Large Stokes shift
Funding
- National Natural Science Foundation of China [21275018, 21575015, 21505004, 21203008]
- Beijing National Laboratory for Molecular Sciences (BNLMS) [20140121]
- Research Fund for the Doctoral Program of Higher Education of China (RFDP) [20121101110049]
- 111 Project [B07012]
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A naphthalimide-based fluorescent probe NACl with a large Stokes shift has been successfully developed for highly sensitive, selective and ultrafast detection of hypochlorite (ClO-). This probe utilizes an oxidative deoximation reaction to provide high selectivity and optical dynamic range for detection of ClO- in aqueous solution. Compared to similar systems involving reactive oxygen species (ROS), including superoxide, tert-butyl hydroperoxide, hydroxyl radical, alkylperoxyl radical, and H2O2, NACl provides 138-fold fluorescence enhancement. Its outstanding response time of less than 3 s and detection limit of 2.88 nM establish the potential value of NACl for interrogating the pathology and physiology of intracellular endogenous ClO-. (C) 2016 Elsevier B.V. All rights reserved.
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