Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 225, Issue -, Pages 453-462Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2015.11.091
Keywords
DNA-templated nanocomposites; Detection of Hg2+; Electrochemical biosensor; chitosan; Three-dimensional reduced graphene oxide
Funding
- Program for the National Natural Science Foundation of China (NSFC) [51173172, 21441003]
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A novel DNA-modified nanocomposite of three-dimensional reduced graphene oxide and chitosan particles (CS@3D-rGO@DNA) was prepared by one-step method and used as a new electrochemical bio sensing strategy to detect Hg2+ in drinking water. This biosensor was fabricated by the chemical coordination of T-Hg2+-T between the T-rich oligonucleotide strands contained in the as-prepared CS@3D-rGO@DNA nanocomposite and Hg2+, thereby varying the electrochemical signals. The developed electrochemical biosensor exhibited high sensitivity toward the determination of Hg2+ with a low detection limit of 0.016 nM, ranging from 0.1 nM to 10 nM. This novel bio sensor also showed high selectivity, good stability, and repeatability. Hence, this proposed CS@3D-rGO@DNA-based electrochemical strategy is feasible and may offer a simple, rapid, cost-effective, highly selective, and sensitive method for Hg2+ quantification. (C) 2015 Elsevier B.V. All rights reserved.
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