Journal
SENSORS
Volume 16, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/s16111871
Keywords
smartphone; microwell reader; mercury ions; colorimetric aptamer nanosensor; gold nanoparticle
Funding
- National Key Research and Development Program of China [2016YFD0500600]
- Technology Research Program of Guangzhou City [201508020100]
- Technology Research Program of Guangdong Province [2013B010404027]
- Guangdong Innovative and Entrepreneurial Research Team Program [201301S0105240297]
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The detection of environmental mercury (Hg) contamination requires complex and expensive instruments and professional technicians. We present a simple, sensitive, and portable Hg2+ detection system based on a smartphone and colorimetric aptamer nanosensor. A smartphone equipped with a light meter app was used to detect, record, and process signals from a smartphone-based microwell reader (MR S-phone), which is composed of a simple light source and a miniaturized assay platform. The colorimetric readout of the aptamer nanosensor is based on a specific interaction between the selected aptamer and Hg2+, which leads to a color change in the reaction solution due to an aggregation of gold nanoparticles (AuNPs). The MR S-phone-based AuNPs-aptamer colorimetric sensor system could reliably detect Hg2+ in both tap water and Pearl River water samples and produced a linear colorimetric readout of Hg2+ concentration in the range of 1 ng/mL-32 ng/mL with a correlation of 0.991, and a limit of detection (LOD) of 0.28 ng/mL for Hg2+. The detection could be quickly completed in only 20 min. Our novel mercury detection assay is simple, rapid, and sensitive, and it provides new strategies for the on-site detection of mercury contamination in any environment.
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