Journal
SENSORS
Volume 16, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/s16111894
Keywords
microspectrometer; fluorescence; dopamine; optical sensing; wireless
Funding
- NASA [NNX12AH22A]
- NSF RISE grant [HRD 1345215]
- NASA [NNX12AH22A, 19704] Funding Source: Federal RePORTER
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Real-time monitoring of extracellular neurotransmitter concentration offers great benefits for diagnosis and treatment of neurological disorders and diseases. This paper presents the study design and results of a miniaturized and wireless optical neurotransmitter sensor (MWONS) for real-time monitoring of brain dopamine concentration. MWONS is based on fluorescent sensing principles and comprises a microspectrometer unit, a microcontroller for data acquisition, and a Bluetooth wireless network for real-time monitoring. MWONS has a custom-designed application software that controls the operation parameters for excitation light sources, data acquisition, and signal processing. MWONS successfully demonstrated a measurement capability with a limit of detection down to a 100 nanomole dopamine concentration, and high selectivity to ascorbic acid (90:1) and uric acid (36:1).
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