Journal
SEMINARS IN PERINATOLOGY
Volume 40, Issue 3, Pages 189-202Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.semperi.2015.12.006
Keywords
Drug Interventions; Retinopathy of Prematurity; Oxygen
Categories
Funding
- NIH-Eunice Kennedy Shriver National Institute of Child Health & Human Development [1U54HD071594]
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Retinopathy of prematurity (ROP), a significant morbidity in prematurely born infants, is the most common cause of visual impairment and blindness in children and persists till adulthood. Strict control of oxygen therapy and prevention of intermittent hypoxia are the keys in the prevention of ROP, but pharmacologic interventions have decreased risk of ROP. Various drug classes such as methylxanthines (caffeine), VEGF inhibitors, antioxidants, and others have decreased ROP occurrence. The timing of pharmacologic intervention remains unsettled, but early prevention rather than controlling disease progression may be preferred. These drugs act through different mechanisms, and synergistic approaches should be considered to maximize efficacy and safety. (C) 2016 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license.
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