Journal
SEMINARS IN IMMUNOLOGY
Volume 28, Issue 1, Pages 22-27Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2015.11.002
Keywords
Cancer immunotherapy; Tumor immunology; Neoantigen; Mutation
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Funding
- Intramural Research Program of National Cancer Institute
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Neoantigens are antigens encoded by tumor-specific mutated genes. Studies in the past few years have suggested a key role for neoantigens in cancer immunotherapy. Here we review the discoveries of neoantigens in the past two decades and the current advances in neoantigen identification. We also discuss the potential benefits and obstacles to the development of effective cancer immunotherapies targeting neoantigens. Published by Elsevier Ltd
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