Journal
SEMINARS IN IMMUNOLOGY
Volume 28, Issue 5, Pages 425-430Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2016.09.002
Keywords
Monocyte; Macrophage; Glycolysis; Epigenetics; Trained immunity; Immunometabolism
Categories
Funding
- ERC Starting Grant [ERC-StG-310372]
- Spinoza Grant of the Netherlands Organization for Scientific Research[NWO]
Ask authors/readers for more resources
The classical view that only adaptive immunity can build immunological memory has recently been challenged. Both in organisms lacking adaptive immunity as well as in mammals, the innate immune system can adapt to mount an increased resistance to reinfection, a de facto innate immune memory termed trained immunity. Recent studies have revealed that rewiring of cellular metabolism induced by different immunological signals is a crucial step for determining the epigenetic changes underlying trained immunity. Processes such as a shift of glucose metabolism from oxidative phosphorylation to aerobic glycolysis, increased glutamine metabolism and cholesterol synthesis, play a crucial role in these processes. The discovery of trained immunity opens the door for the design of novel generations of vaccines, for new therapeutic strategies for the treatment of immune deficiency states, and for modulation of exaggerated inflammation in autoinflammatory diseases. (C) 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available