Journal
SEMINARS IN IMMUNOLOGY
Volume 28, Issue 5, Pages 417-424Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2016.10.004
Keywords
Inflammation; Metabolism; Glycolysis; Mitochondria; Nitric oxide
Categories
Funding
- National Institute of Health [RO1 DK11003401]
- Diabetes Research Center [P30 DK02057937]
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Macrophages are heterogeneous cells that play a key role in inflammatory and tissue reparative responses. Over the past decade it has become clear that shifts in cellular metabolism are important determinants of macrophage function and phenotype. At the same time, our appreciation of macrophage diversity in vivo has also been increasing. Factors such as cell origin and tissue localization are now recognized as important variables that influence macrophage biology. Whether different macrophage populations also have unique metabolic phenotypes has not been extensively explored. In this article, we will discuss the importance of understanding how macrophage origin can modulate metabolic programming and influence inflammatory responses. (C) 2016 Elsevier Ltd. All rights reserved.
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