Journal
SEMINARS IN IMMUNOLOGY
Volume 28, Issue 2, Pages 137-145Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2016.03.007
Keywords
Neutrophil; Inflammation; Resolution; Repair
Categories
Funding
- Medical Research Council UK [MR/K013386/1, MR/K013068/1]
- Wellcome Trust [086867/Z/08/Z]
- British Heart Foundation UK
- BBSRC [BB/K011782/1]
- Wellcome Trust [086867/Z/08/Z] Funding Source: Wellcome Trust
- BBSRC [BB/K011782/1] Funding Source: UKRI
- MRC [MR/K013068/1, G0901697, G0601481, MR/K013386/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [1368331] Funding Source: researchfish
- Medical Research Council [MR/K013386/1, MR/K013068/1, G0901697, G0601481] Funding Source: researchfish
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The fundamental role played by neutrophils for an efficient, acute inflammatory response has long been appreciated, with the underlying molecular and cellular mechanisms largely elucidated over the past decades. However, more recent work suggests that the biological functions exerted by this fascinating leucocyte are somewhat more extensive than previously acknowledged. Here we discuss how extravasated neutrophils govern the initiation of the resolution phase of inflammation by enabling activation of pro resolving circuits to ensure the safe conclusion of the inflammatory response. The neutrophil 'alarm bell' on resolution is effected through release of soluble mediators as well as apoptotic bodies and other vesicles, which, in turn, can inform and modify the microenvironment ultimately leading to termination of the inflammatory response coinciding with re-establishment of tissue homeostasis and functionality. (C) 2016 Elsevier Ltd. All rights reserved.
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