Journal
SEMINARS IN IMMUNOLOGY
Volume 28, Issue 1, Pages 10-21Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2016.03.002
Keywords
Antigen recognition; Immune evasion; T cell; T cell receptor; T cell trafficking; Tumor micro-environment
Categories
Funding
- European Community (ATTACK2), 7th fw [305863]
- Dutch Cancer Society [EMCR2014-7087, EMCR2015-7741, WUR2015-7734]
- Erasmus MC
Ask authors/readers for more resources
Adoptive transfer of T cells gene-engineered with T cell receptors (TCRs) has proven its feasibility and therapeutic potential in the treatment of malignant tumors. To ensure further clinical development of TCR gene therapy, it is necessary to accurately select TCRs that demonstrate antigen-selective responses that are restricted to tumor cells and, at the same time, include strategies that restore or enhance the entry, migration and local accumulation of T cells in tumor tissues. Here, we present the current standing of TCRengineered T cell therapy, discuss and propose procedures to select TCRs as well as strategies to sensitize the tumor to T cell trafficking, and provide a rationale for combination therapies with TCR-engineered T cells. (C) 2016 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available