Journal
SEMINARS IN FETAL & NEONATAL MEDICINE
Volume 21, Issue 5, Pages 339-348Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.siny.2016.04.014
Keywords
Cerebellum; Disruption; Prenatal; Magnetic resonance imaging; Neurodevelopment; Disability
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The vulnerability of the cerebellum during prenatal life to disruptive events such as hemorrhage and infection leads to a wide variety of morphological abnormalities. This review discusses various prenatal cerebellar disruptions including cerebellar agenesis, unilateral cerebellar hypoplasia, cerebellar cleft, global cerebellar hypoplasia, and vanishing cerebellum in Chiari type II malformation. For each entity, we discuss the definition, potential pathomechanism, clinical findings including neurocognitive and behavioral problems, neuroimaging features, and management. Accurate recognition of cerebellar disruptions and their differentiation from malformations is important in terms of diagnosis, prognosis, and genetic counselling. (C) 2016 Elsevier Ltd. All rights reserved.
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