Journal
SEMINARS IN DIAGNOSTIC PATHOLOGY
Volume 33, Issue 5, Pages 294-306Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.semdp.2016.05.006
Keywords
Castleman disease; Kaposi sarcoma-associated herpesvirus; Human herpesvirus type-8; Interleukin-6; TAFRO syndrome; Acquired immune deficiency syndrome
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Multicentric Castleman disease (MCD) encompasses a spectrum of conditions that give rise to overlapping clinicopathological manifestations. The fundamental pathogenetic mechanism involves dysregulated cytokine activity that causes systemic inflammatory symptoms as well as lymphadenopathy. The histological changes in lymph nodes resemble in part the findings originally described in the unicentric forms Castleman disease, both hyaline vascular and plasma cell variants. In MCD caused by Kaposi sarcoma-associated herpesvirus/human herpesvirus-8 (KSHV/HHV8), the cytokine over activity is caused by viral products, which can also lead to atypical lymphoproliferations and potential progression to lymphoma. In cases negative for KSHV/HHV8, so-called idiopathic MCD, the hypercytokinemia can result from various mechanisms, which ultimately lead to different constellations of clinical presentations and varied pathology in lymphoid tissues. In this article, we review the evolving concepts and definitions of the various conditions under the eponym of Castleman disease, and summarize current knowledge regarding the histopathology and pathogenesis of lesions within the MCD spectrum. Published by Elsevier Inc.
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