Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 54, Issue -, Pages 2-10Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2015.09.001
Keywords
Computed tomography; Cancer; Muscle; Fat
Categories
Funding
- Alberta Innovates Health Solutions Graduate Studentship award
- Izaak Walton Killam Memorial Scholarship
- Alberta Innovates [201201091] Funding Source: researchfish
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Cancer cachexia (i.e., skeletal muscle wasting with or without fat loss) relates to several adverse outcomes. Computed tomography (CT) cross-sectional images serve as an efficient biomarker for assessment of cachexia in cancer patients. We systematically reviewed literature reporting quantitative evaluation of the cross sectional area of the main tissues implicated in cancer cachexia, muscle and visceral, subcutaneous and inter-muscular fat in CT scans at the 3rd lumbar vertebra. Our main goal was to summarize CT-defined variation of muscle and fat and the relationship between these features and cancer outcomes such as chemotherapy toxicity, post-surgery complications and survival. (C) 2015 Elsevier Ltd. All rights reserved.
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