Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 59, Issue -, Pages 10-26Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2016.04.009
Keywords
Human spermatogenesis; Sperm; Reproduction; Male infertility; Genetics; Testis; Testosterone; Varicocele; Germ cells
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Spermatogenesis is an extraordinary complex process. The differentiation of spermatogonia into spermatozoa requires the participation of several cell types, hormones, paracrine factors, genes and epigenetic regulators. Recent researches in animals and humans have furthered our understanding of the male gamete differentiation, and led to clinical tools for the better management of male infertility. There is still much to be learned about this intricate process. In this review, the critical steps of human spermatogenesis are discussed together with its main affecting factors. (C) 2016 Elsevier Ltd. All rights reserved.
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